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Epidermodysplasia verruciformis (EV) is a rare inherited disease. It is a lifelong, viral-mediated, autosomal recessive (Sex-linked1 and autosomal dominant inheritance patterns have also been reported.) disorder affecting the skin. The disease is characterized by chronic infection with human papillomavirus (HPV). Widespread skin eruptions of flat-to-papillomatous, wartlike lesions and reddish-brown pigmented plaques on the trunk, the hands, the upper and lower extremities, and the face are typical.
The lesions may transform into malignant skin tumors (carcinomas), usually after age 30 years. Skin cancers initially appear on sun-exposed areas, such as the face and the ear lobes. Patients with EV are usually infected with multiple types of HPV, including “common” types affecting normal individuals (HPV -3,10) and those unique to EV, that are so named “EV HPVs.” More than 30 EV HPVs, such as types 4, 5a, 5b, 8-9, 12, 14, 15, 17, 19-21, 23-26, 36-38, 47, and 50 have been identified in EV lesions. The EV HPVs are detected in up to 20% of the normal population, and they are only pathogenic in EV patients. HPV-5 and HPV-8 have been isolated in more than 90% of EV-associated squamous cell carcinomas. source.
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Citation Details
Title: Epidermodysplasia verruciformis. (Case Report).
Author: Joshua E. Lane
Publication: Southern Medical Journal (Refereed)
Date: June 1, 2003
Publisher: Southern Medical Association
Volume: 96 Issue: 6 Page: 613(3)
Distributed by Thomson Gale
